Had genetic testing but still no answers? We specialize in clinically focused reinterpretation to uncover what matters for your health.
What Can Your DNA Tell You?
Top Actionable DNA Discoveries for People Who Want to Stay Well
| Category | What DNA Can Reveal | Why It Matters | What You Can Do About It |
|---|---|---|---|
| Heart Health | Risk for high cholesterol or early heart attacks (e.g., familial hypercholesterolemia) | You could be at risk even if your current cholesterol is normal | Early cholesterol testing, lifestyle changes, and preventive medications if needed |
| Blood Clotting | Inherited clotting disorders (e.g., Factor V Leiden) | Increases risk of DVT or stroke, especially during surgery or pregnancy | Avoid hormone-based medications, consider preventive measures before long travel or surgery |
| Cancer Risk | Genetic risks for cancers (e.g., BRCA1/2, Lynch syndrome) | Early detection saves lives | More frequent screenings, preventive procedures, share info with family |
| Medication Reactions | How your body processes medications (e.g., antidepressants, painkillers, statins) | Reduces risk of side effects or treatment failure | Choose safer or more effective medications based on your genes |
| Blood Sugar & Diabetes | Predisposition to type 2 diabetes or insulin resistance | You may be at risk even if your weight and labs are normal | Track blood sugar early, adopt a diabetes-preventive diet |
| Vitamin Processing | Trouble activating folate (MTHFR), B12, or vitamin D | Could lead to fatigue, anxiety, or inflammation despite taking supplements | Choose the right supplement form (e.g., methylfolate, active B12) |
| Brain Health | Risk genes for Alzheimer’s, Parkinson’s, or cognitive decline (e.g., APOE4) | Early brain health decisions can help reduce risk | Focus on diet, sleep, exercise, cognitive training, and preventive therapies |
| Food & Diet Response | Sensitivity to carbs, fats, or lactose | Not all diets work for everyone | Pick a diet plan that fits your genes (e.g., Mediterranean, low-carb, dairy-free) |
| Fitness & Muscle Genes | Muscle type, injury risk, or recovery speed | Knowing your baseline helps optimize workouts | Personalize your training, avoid overtraining, tailor rest periods |
| Carrier Status | Whether you carry silent genetic risks for future children | You may be healthy but carry a hidden condition (e.g., cystic fibrosis, SMA) | Useful when planning a family; your partner can be tested too |
| ACMG Actionable Genes | Variants in medically actionable genes (ACMG secondary findings list ACMG SF v3.2) | Early detection and intervention can prevent or mitigate life‑threatening conditions | Review with a genetics-trained physician, schedule condition‑specific screenings, and consider preventive treatments |
What We Do
We identify disease-causing pathogenic variants following ACMG guidelines.
Our Technology here
Who We Are
Founded by a practicing physician with expertise in bioinformatics and genomics.
Read About Us here
The Benefits
Our reports enable your healthcare provider to streamline medical follow-ups, tests, and referrals, enhancing your treatment and disease prevention.
Sample Report here
A few MORE things we’re great at
Comprehensive Genetic Testing for 15,000+ Conditions
Asperger’s Syndrome, Autism Spectrum Disorders
Nonverbal Autism
Asperger’s Syndrome
Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)
Childhood Disintegrative Disorder
ADHD, Severe Anxiety, Treatment-Resistant Depression
Attention Deficit Hyperactivity Disorder (ADHD)
Generalized Anxiety Disorder (GAD)
Obsessive-Compulsive Disorder (OCD)
Persistent Major Depressive Disorder (MDD)
Bipolar Disorder with Treatment-Resistant Depression
Cases Where Medications Are Ineffective or Cause Severe Side Effects
Pharmacogenomic Issues (e.g., variations in enzymes affecting drug metabolism)
Adverse Drug Reactions (e.g., Stevens-Johnson Syndrome, Drug-Induced Lupus)
Multiple Drug Allergies or Sensitivities
Genetic Risk for Alzheimer’s: APOE Genotype
Are you experiencing unexplained memory loss? Family history of dementia? Let MoodNote Genomics help you find the answers you need to start feeling better. Take your APOE genotype test today as the first step towards a healthier you.
Seizures
Down Syndrome
Fragile X Syndrome
Rett Syndrome
Lennox-Gastaut Syndrome
Dravet Syndrome
Skin, Sensory, or Digestive Issues
Eczema (Atopic Dermatitis)
Psoriasis
Sensory Processing Disorder
Irritable Bowel Syndrome (IBS)
Crohn’s Disease
Celiac Disease
Why Choose Us?
Most sequencing services rely on software engineers — we rely on physicians
Physician-Led Expertise
Unlike most genetic testing services that rely on software engineers and automated reports, our interpretation is led by physicians trained in clinical genomics. We connect your DNA results to your symptoms, your health history, and real medical decision-making.
Clinical Integration and Personalization
At MyGenePortal, we don’t just identify mutations — we interpret them in context. We evaluate the clinical relevance of each variant, generate differential diagnoses, and recommend laboratory tests, imaging, referrals, and lifestyle changes based on your unique profile.
Proven Accuracy
We use high-depth sequencing (100×) with > 99.5% base accuracy and > 89% clinical classification accuracy. Our analysis includes all ACMG-recommended actionable genes — a curated list of genetic variants identified by the American College of Medical Genetics and Genomics as medically significant. These genes are associated with conditions that are preventable or treatable if detected early, such as certain cancers, heart disorders, and metabolic diseases.
Clear, Actionable Results
We translate complex genetic data into simple, meaningful insights. Our reports include clear next steps — not vague summaries — and our AI tools allow for interactive exploration of your data when desired.
Timely Turnaround
Receive your results in 4 weeks or less, including DNA extraction, high-depth sequencing, and comprehensive clinical reporting.
Transparent Pricing
We offer competitive and clearly explained pricing options. No surprise fees, no hidden upsells. Visit our Pricing page to learn more.
How Do We Compare to Other Labs?
Most sequencing companies provide a list of gene variants and a disclaimer. We provide something more — a physician-reviewed medical report that fits into your care. Here’s how we compare:
Testimonials
From Our Customers – Real Results, Real People
“I had been struggling with finding the right pain medication for what felt like forever. Whatever my doctor prescribed either didn’t work, or gave me side effects I couldn’t tolerate. It was frustrating and disheartening, especially when everyone seemed to suggest that it was my fault, or that I was being a complainer.
When I read that my genes might be affecting how I respond to medications, I decided to look into it. That’s when I discovered MoodNote Genomics. They were fantastic from the start. All I had to do was to upload my ancestry data that I already had.
What they found was a game-changer: my genes were preventing the prescribed drugs from being effective. Armed with this information, my doctor was able to choose a medication that worked with my genetic makeup. The difference has been incredible. For the first time in years, I feel like myself again.
MoodNote Genomics helped me finally find the right treatment. Their service was easy, affordable, and, most importantly, it worked. If you’re having trouble with your medications, I highly recommend giving them a try.”
Susan, age 55
Educator
“I was always looking for something new to help with my migraines because no matter what medications I tried, I ended up with side effects. I hated the upset stomachs, dizziness, and drowsiness almost as much as I hated the migraines. After someone suggested that maybe my problem was related to my genes, I started looking for companies that could investigate this. MoodNote Genomics was exactly what I was looking for. For a very reasonable price, they had me do a simple cheek swab to collect my genetic material for analysis and then interpreted the raw data for me.
What they found was that I have a mutation in a gene needed to process folic acid. They explained to me that folic acid is a nutrient important for many functions, including blood flow in the brain, heart health, and mood. Even though I had plenty of folic acid in my diet, I was unable to make use of it without this gene. They told me about a specific over-the-counter supplement that would bypass this mutation and provide my body with the folic acid it needed. Since I started taking this supplement, I have not had a single migraine. I am so grateful that I found MoodNote Genomics—they were able to provide an explanation and a simple solution for a problem I had been struggling with for years.“
E.B. age 65
Financial Advisor
Clients & Partners
Contact us for more information
DISCLAIMER
MoodNote and MyGenePortal.com are not healthcare providers. The content on MyGenePortal.com is intended only for educational and informational purposes and should not be used to diagnose, treat, or prevent any medical, psychological, or psychiatric condition.
The DNA‐variant interpretations presented here are not a substitute for professional medical advice. Only a licensed healthcare provider, after a direct and comprehensive clinical evaluation, can make medical diagnoses or recommend appropriate care.
If you have any health concerns, please consult a qualified healthcare professional licensed in your jurisdiction. In case of a medical emergency or if you are experiencing suicidal thoughts, dial 911 (in the U.S. or Canada) or go to your nearest emergency department immediately.
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